Celebrex Drug Prescribing Information, Consumer Information, Side Effects and Interactions
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CELEBREX
========
Generic Name: celecoxib (oral) (seh leh COCK sib)
Brand Names: Celebrex
What is the most important information I should know about celecoxib?
---------------------------------------------------------------------
•
Recent information suggests a possible increased risk for heart attack
and stroke in patients taking celecoxib. The relevance of this
information is still not known. Ask your doctor if celecoxib is right
for you.
•
Do not take celecoxib without first talking to your doctor if you have
experienced asthma, hives, or an allergic reaction after taking a
sulfa-based medication such as sulfamethoxazole (Bactrim, Septra,
Gantanol, and others) or sulfisoxazole (Gantrisin); aspirin; or
another NSAID such as valdecoxib (Bextra), ibuprofen (Motrin, Advil,
Nuprin, and others), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen
(Orudis KT, Orudis, Oruvail), diclofenac (Voltaren, Cataflam),
diflunisal (Dolobid), etodolac (Lodine, Lodine XL), fenoprofen
(Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac
(Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin
(Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin
(Tolectin). You may experience a similar reaction to celecoxib.
•
Notify your doctor immediately if you develop abdominal pain,
tenderness, or discomfort; nausea; bloody vomit; bloody, black, or
tarry stools; unexplained weight gain; swelling or water retention;
fatigue or lethargy; a skin rash; itching; yellowing of the skin or
eyes;"flu-like" symptoms; or unusual bruising or bleeding. These
symptoms could be early signs of dangerous side effects.
What is celecoxib?
------------------
•
Celecoxib is in a class of drugs called nonsteroidal anti-inflammatory
drugs (NSAIDs). Celecoxib works by reducing substances that cause
inflammation, pain, and fever in the body.
•
Celecoxib is used to reduce pain, inflammation, and stiffness caused
by osteoarthritis and rheumatoid arthritis. Celecoxib is also used to
reduce the number of adenomatous colorectal polyps in familial
adenomatous polyposis (FAP), to treat acute pain, and to treat pain
associated with menstruation.
•
Celecoxib may also be used for purposes other than those listed in
this medication guide.
What should I discuss with my healthcare provider before taking
celecoxib?
---------------------------------------------------------------
•
Recent information suggests a possible increased risk for heart attack
and stroke in patients taking celecoxib. The relevance of this
information is still not known. Ask your doctor if celecoxib is right
for you.
•
Do not take celecoxib without first talking to your doctor if you have
experienced asthma, hives, or an allergic reaction after taking a
sulfa-based medication such as sulfamethoxazole (Bactrim, Septra,
Gantanol, and others) or sulfisoxazole (Gantrisin); aspirin; or
another NSAID such as valdecoxib (Bextra), ibuprofen (Motrin, Advil,
Nuprin, and others), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen
(Orudis KT, Orudis, Oruvail), diclofenac (Voltaren, Cataflam),
diflunisal (Dolobid), etodolac (Lodine, Lodine XL), fenoprofen
(Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac
(Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin
(Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin
(Tolectin). You may experience a similar reaction to celecoxib.
•
Before taking celecoxib, tell your doctor if you
·
smoke;
·
drink alcohol;
·
have an ulcer or bleeding in the stomach;
·
have liver disease;
·
have kidney disease;
·
have asthma;
·
have congestive heart failure;
·
have fluid retention;
·
have heart disease;
·
have high blood pressure;
·
have a coagulation (bleeding) disorder or are taking an anticoagulant
(blood thinner) such as warfarin (Coumadin); or
·
are taking a steroid medicine such as prednisone (Deltasone and
others), methylprednisolone (Medrol and others), prednisolone
(Prelone, Pediapred, and others), and others.
•
You may not be able to take celecoxib, or you may require a dosage
adjustment or special monitoring during treatment if you have any of
the conditions, or are taking any of the medicines, listed above.
•
Celecoxib is in the FDA pregnancy category C. This means that it is
not known whether it will harm an unborn baby. Celecoxib should not be
taken late in pregnancy (the third trimester) because it may affect
the formation of the baby's heart. Do not take celecoxib without first
talking to your doctor if you are pregnant.
•
It is not known whether celecoxib passes into breast milk. Do not take
celecoxib without first talking to your doctor if you are
breast-feeding.
•
If you are over the age of 65 years, you may be more likely to
experience side effects from celecoxib. You may require a lower dosage
or special monitoring during your therapy.
How should I take celecoxib?
----------------------------
•
Take celecoxib exactly as directed by your doctor. If you do not
understand these instructions, ask your pharmacist, nurse, or doctor
to explain them to you.
•
Take each dose with a full glass of water.
•
Celecoxib can be taken with or without food or milk. Follow your
doctor's instructions.
•
Your doctor may want you to have blood tests or other medical
evaluations during treatment with celecoxib to monitor progress and
side effects.
•
Store celecoxib at room temperature away from moisture and heat.
What happens if I miss a dose?
------------------------------
•
Take the missed dose as soon as you remember. If it is almost time for
the next dose, skip the dose you missed and take only the next
regularly scheduled dose as directed. Do not take a double dose of
this medication unless your doctor directs otherwise.
What happens if I overdose?
---------------------------
•
Seek emergency medical attention.
•
Symptoms of a celecoxib overdose include drowsiness, nausea, vomiting,
stomach pain, dizziness, headache, ringing in the ears, blurred
vision, little or no urine production, slow breathing, and coma.
What should I avoid while taking celecoxib?
-------------------------------------------
•
There are no restrictions on food, beverages, or activity while taking
celecoxib unless otherwise directed by your doctor.
What are the possible side effects of celecoxib?
------------------------------------------------
•
Notify your doctor immediately if you develop abdominal pain,
tenderness, or discomfort; nausea; bloody vomit; bloody, black, or
tarry stools; unexplained weight gain; swelling or water retention;
fatigue or lethargy; a skin rash; itching; yellowing of the skin or
eyes;"flu-like" symptoms; or unusual bruising or bleeding. These
symptoms could be early signs of dangerous side effects.
•
If you experience any of the following serious side effects, stop
taking celecoxib and seek medical treatment or call your doctor
immediately:
·
an allergic reaction (difficulty breathing; closing of your throat;
swelling of your lips, tongue, or face; or hives);
•
Other, less serious side effects may be more likely to occur. Continue
to take celecoxib and talk to your doctor if you experience
·
flatulence or diarrhea;
·
dizziness;
·
headache; or
·
insomnia.
•
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially
bothersome.
What other drugs will affect celecoxib?
---------------------------------------
•
Before taking celecoxib, tell your doctor if you are taking any of the
following drugs:
·
aspirin or another salicylate (form of aspirin) such as salsalate
(Disalcid), choline salicylate-magnesium salicylate (Trilisate,
Tricosal, others), and magnesium salicylate (Doan's, Bayer Select
Backache Formula, others);
·
an over-the-counter cough, cold, allergy, or pain medicine that
contains aspirin, ibuprofen, naproxen, or ketoprofen;
·
a diuretic (water pill) such as furosemide (Lasix),
hydrochlorothiazide (HydroDiuril, others), chlorothiazide (Diuril,
others), chlorthalidone (Hygroton, Thalitone), and others;
·
an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as
benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec),
lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril
(Accupril), and others;
·
a steroid medicine such as prednisone (Deltasone and others),
methylprednisolone (Medrol and others), prednisolone (Prelone,
Pediapred, and others), and others;
·
an anticoagulant (blood thinner) such as warfarin (Coumadin);
·
lithium (Eskalith, Lithobid, others); or
·
fluconazole (Diflucan).
•
You may not be able to take celecoxib, or you may require a dosage
adjustment or special monitoring during treatment if you are taking
any of the medicines listed above.
•
Drugs other than those listed here may also interact with celecoxib.
Talk to your doctor and pharmacist before taking any prescription or
over-the-counter medicines including vitamins, minerals, and herbal
products.
Where can I get more information?
---------------------------------
•
Your pharmacist has additional information about celecoxib written for
health professionals that you may read.
---------------------------------------------------------------------
•
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
•
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in
caring for their patients and/ or to serve consumers viewing this
service as a supplement to, and not a substitute for, the expertise,
skill, knowledge and judgment of healthcare practitioners. The absence
of a warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein
is not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects.
If you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
Copyright 1996-2005 Cerner Multum, Inc. Version: 7.01. Revision date:
1/ 14/ 05.
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information available.
The information contained in MULTUM data is intended as an
educational aid only. It is not intended as medical advice for
individual conditions or treatment.View full disclaimer
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